Genome-wide association studies (GWAS) have identified over 170 common breast cancer susceptibility variants using standard GWAS methods. Many of these variants have differential associations by estrogen receptor (ER), but how these variants relate …
Background:Past history of gallstones is associated with increased risk of gallbladder cancer (GBC) in observational studies. We conducted complementary observational and Mendelian Randomization (MR) analyses to determine whether history of …
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 …
Cancers are routinely classified into subtypes according to various features, including histopathological characteristics and molecular markers. Previous genome-wide association studies have reported heterogeneous associations between loci and cancer …
Background: The International Agency for Research on Cancer (IARC) classifies diesel engine exhaust as carcinogenic to humans based on sufficient evidence for lung cancer. IARC noted, however, an increased risk of bladder cancer (based on limited …
This is the first GWAS of gallbladder cancer in India. We identified several genome-wide significant associations for several markers in the chromosomal region 7q21.12 harbouring both the *ABCB1* and *ABCB4* genes.